Currently we have rebindable controls, color blindness mitigations (both through a color filter and by naming colors wherever relevant, e.g. in the character customizer), and UI scale for creation mode.
Because of the type of game Crayta is, it's difficult to provide game-specific accessibility features. However, one of our launch games (Crayta Sprint League) was chosen specifically because of the developer's intention to make it accessible via a single-button control mode.
Accessibility is important to us, and we're constantly looking at ways in which we can make Crayta more accessible. If there are specific accommodations that would help you to play Crayta, please post on our feature request board so we can make sure we're adding functionality that would be helpful to our players (or would-be players!).